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Study 3, conducted in patients with GEP-NET, did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients.

Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

It is not necessary to alter the starting dose in elderly patients; lanreotide serum concentrations in the elderly are well within the range of serum concentrations safely tolerated in healthy young subjects. No dose adjustment required. Lanreotide has been studied in patients with end-stage renal function on dialysis , but has not been studied in patients with mild, moderate, or severe renal impairment. It is recommended that patients with moderate or severe renal impairment receive a starting dose of lanreotide of 60 mg.

It is recommended that patients with moderate or severe hepatic impairment receive a starting dose of lanreotide of 60 mg. Up-to-date information about the treatment of overdose can often be obtained from the National Poison Control Center at phone number The mechanism of action of lanreotide is believed to be similar to that of natural somatostatin. Like somatostatin, lanreotide is an inhibitor of various endocrine, neuroendocrine , exocrine , and paracrine functions.

In acromegalic patients, lanreotide reduces GH levels in a dose-dependent way. Lanreotide inhibits the basal secretion of motilin, gastric inhibitory peptide , and pancreatic polypeptide , but has no significant effect on the secretion of secretin.

Lanreotide inhibits postprandial secretion of pancreatic polypeptide, gastrin, and cholecystokinin CCK. In healthy subjects, lanreotide produces a reduction and a delay in postprandial insulin secretion, resulting in transient, mild glucose intolerance.

Lanreotide inhibits meal-stimulated pancreatic secretions, and reduces duodenal bicarbonate and amylase concentrations, and produces a transient reduction in gastric acidity. In healthy subjects, lanreotide inhibits meal-induced increases in superior mesenteric artery and portal venous blood flow, but has no effect on basal or meal-stimulated renal blood flow.

Lanreotide has no effect on renal plasma flow or renal vascular resistance. However, a transient decrease in glomerular filtration rate GFR and filtration fraction has been observed after a single injection of lanreotide. In healthy subjects, non-significant reductions in glucagon levels were seen after lanreotide administration.

Serum glucose concentrations returned to normal levels within 24 hours. Lanreotide inhibits the nocturnal increase in thyroid -stimulating hormone TSH seen in healthy subjects. Lanreotide reduces prolactin levels in acromegalic patients treated on a long-term basis. The most likely mechanism of drug release is a passive diffusion of the precipitated drug from the depot towards the surrounding tissues, followed by the absorption to the bloodstream.

Mean C max values ranged from 4. Single-dose linearity was demonstrated with respect to AUC and Cmax , and showed high inter-subject variability. In a repeat-dose administration pharmacokinetics PK study in acromegalic patients, rapid initial release was seen giving peak levels during the first day after administration.

At steady state, mean C max values were 3. The mean accumulation ratio index was 2. For the same doses, similar values were obtained in clinical studies after at least four administrations 2. Age has no effect on clearance of lanreotide based on population PK analysis in patients with GEP-NET which included patients aged 65 to 85 years with neuroendocrine tumors.

An approximate 2-fold decrease in total serum clearance of lanreotide, with a consequent 2-fold increase in half-life and AUC was observed.

This one-year study included a 4-week, double-blind, placebo-controlled phase; a week single-blind , fixed-dose phase; and a week, open-label, dose-titration phase. Patients with active acromegaly, based on biochemical tests and medical history , entered a week washout period if there was previous treatment with a somatostatin analog or a dopaminergic agonist.

Injections were given at 4-week intervals. During the dose-titration phase of the study, the dose was titrated twice every fourth injection , as needed, according to individual GH and IGF-1 levels.

A total of patients 51 males, 57 females were enrolled in the initial placebo-controlled phase of the study. One hundred and seven patients completed the placebo-controlled phase, patients completed the fixed-dose phase, and 99 patients completed the dose-titration phase. Patients not completing withdrew due to adverse events 5 or lack of efficacy 4. Efficacy achieved in the first 16 weeks was maintained for the duration of the study see Table 4.

Patients titrated up to the maximum dose mg were not allowed to titrate down again. A total of 63 patients 38 males, 25 females entered the fixed-dose phase of the trial and 57 patients completed 48 weeks of treatment. Six patients withdrew due to adverse reactions 3 , other reasons 2 , or lack of efficacy 1. Mean IGF-1 concentrations after treatment completion were 1. The reduction in IGF-1 concentrations over time correlated with a corresponding marked decrease in mean GH concentrations.

Patients were required to have non-functioning tumors without hormone-related symptoms. Patients were randomized 1: Randomization was stratified by the presence or absence of prior therapy and by the presence or absence of disease progression within 6 months of enrollment. Disease progression was present in nine of patients 4. There may be new information. This information does not take the place of talking with your healthcare professional about your medical condition or your treatment.

Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare professional when you get a new medicine. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

These topical anesthetics contain anesthetic drugs such as lidocaine, tetracaine, benzocaine, and prilocaine in a cream, ointment, or gel. Such drugs were usually known as anodynes before the 20th century. Some novel and investigational analgesics include subtype-selective voltage-gated sodium channel blockers such as funapide and raxatrigine , as well as multimodal agents such as ralfinamide.

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Archived from the original on 14 April Archived from the original on March 3, Retrieved December 3, Analgesics N02A , N02B. Meclofenamic acid Mefenamic acid. Cannabidiol Cannabis Nabilone Nabiximols Tetrahydrocannabinol dronabinol. Gabapentin Gabapentin enacarbil Pregabalin Ziconotide. Carbamazepine Lacosamide Local anesthetics e. Emollients Cicatrizants Antipruritics Antipsoriatics Medicated dressings. Anticancer agents Antimetabolites Alkylating Spindle poisons Antineoplastic Topoisomerase inhibitors.

Decongestants Bronchodilators Cough medicines H 1 antagonists. Antidotes Contrast media Radiopharmaceuticals Dressings Senotherapeutics. Retrieved from " https: Analgesics Pain Opioids Agnosia.

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Vérifiez la taille minimum de la buse de pulvérisateur nécessaire indiquée sur le produit à pulvériser puis comparez-la avec la taille maximum de la buse de pulvérisateur de peinture que vous souhaitez acheter. Les pulvérisateurs de peinture Graco sont tous compatibles avec une taille de buse maximum. En général, les produits plus larges destinés aux professionnels permettent de pulvériser des matériaux plus épais nécessitant une taille de buse plus large.

Tous les pulvérisateurs ne sont pas conçus pour les professionnels qui pulvérisent à plein temps. Graco propose des pulvérisateurs d'entrée de gamme conçus pour les particuliers ayant de petits projets, mais également des pulvérisateurs destinés aux professionnels conçus pour répondre aux besoins des peintres à plein temps.

Les Magnum, nos pulvérisateurs d'entrée de gamme, sont conçus aussi bien pour les particuliers que pour les professionnels occasionnels. Notre gamme de pulvérisateurs destinée aux professionnels est conçue pour les personnes qui cherchent à utiliser leurs appareils dans le cadre de leur travail, et qui ont besoin de polyvalence afin de pulvériser une large variété de produits. Les matériaux et la qualité de la finition diffèrent en fonction du type de surface.

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